Novartis acquires Avidity Biosciences to boost xRNA strategy

Highlights of the report

Novartis agreed to acquire Avidity for $72.00 per share in cash, valuing the company at about $12 billion on a fully diluted basis and roughly $11 billion enterprise value at expected close. The price reflects a 46% premium to Avidity’s October 24, 2025 close and 62% to the 30-day VWAP, with closing targeted for H1 2026 subject to regulatory approvals, shareholder vote, and completion of a cardiology SpinCo separation.

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Novartis’s View: Novartis frames the deal as a strategic move to strengthen its late
stage neuroscience pipeline and expand leadership in RNA therapeutics by adding
Avidity’s AOC platform for targeted muscle delivery and three late-stage programs
(DM1, FSHD, DMD). 

Avidity Biosciences, Inc. (RNA.O) is a clinical-stage biopharmaceutical company
revolutionizing RNA therapeutics through its proprietary Antibody Oligonucleotide Conjugate (AOC ) platform, targeting the root causes of rare neuromuscular diseases and expanding into precision cardiology and
immunology.

While Novartis achieved 7% constant currency sales growth in Q3FY25, exclusion of 9% points from gross-to-net adjustments reveals underlying operational growth of ~9%. Management guidance forecasts high single-digit sales growth in 2025 and low-teens coreoperating income growth.

Executive Summary
• Executive Summary………………….…………………………………………………………..3
• Deal Overview………………………….………………………………………………………….5
• Business Rationale………………………………………………………………………………..6
• Company Overview – Avidity Biosciences..….………….………………………….13
• Company Overview – Novartis AG…….…..………….…………………………….…..2

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Report details

Novartis acquires Avidity Biosciences to boost xRNA strategy

Price

$416.00

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